Researchers use AI to discover 14 distinct nucleosome states, revealing that DNA packaging acts as a "volume dial" for gene ...

Researchers have discovered that DNA wrapped around nucleosomes exists in multiple partially open states rather than simply ...

Barcelona, 10 October 2024 - DNA—the molecule that carries the genetic information of all living organisms—is packaged within cells in a complex manner that allows it to function efficiently.

Using an AI-driven approach, researchers found DNA within nucleosomes is often partly exposed, enabling nuanced gene ...

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone cross-links (DHCs) occur frequently within ...

Chromatin remodeling plays a vital role in gene regulation, affecting how DNA is accessed. Disruptions in this process can also lead to cancer and other diseases. To better understand how chromatin ...

K. Luger, A.W. Mader, R.K. Richmond, D.F. Sargent, T.J. Richmond, "Crystal structure of the nucleosome core particle at 2.8 Å resolution," Nature, 389:251-60, 1997 ...

Every cell in the human body squeezes over six feet of DNA into a miniscule speck invisible to the naked eye—like ...